Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

Hyp mice possess a mutation that inactivates the phosphate-regulating gene, which is homologous to the endopeptidases of the X-chromosome (PHEX). The mutation is associated with severe hypophosphatemia due to excessive urinary phosphate wasting. Such urinary phosphate wasting in Hyp mice is associat...

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Bibliografiska uppgifter
Huvudupphovsmän: Nakatani, Teruyo, Ohnishi, Mutsuko, Razzaque, M. Shawkat
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Federation of American Societies for Experimental Biology 2009
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775000/
https://ncbi.nlm.nih.gov/pubmed/19584304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-123992
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