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Identification and Optimization of a Novel Inhibitor of Mitochondrial Calpain 10
Calpain 10 has been localized to the mitochondria and is a key mediator of Ca(2+) induced mitochondrial dysfunction. A peptide screen followed by a series of modifications identified the homodisulfide form of CYGAK (CYGAK)(2) as an inhibitor of calpain 10, while showing no inhibitory activity agains...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801808/ https://ncbi.nlm.nih.gov/pubmed/19072163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800735d |
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