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Loss of Calpain 10 Causes Mitochondrial Dysfunction during Chronic Hyperglycemia

We showed that renal calpain 10, a mitochondrial and cytosolic Ca(2+)-regulated cysteine protease, is specifically decreased in kidneys of diabetic rats and mice, and is associated with diabetic nephropathy. The goals of this study were to examine renal calpain 10 and mitochondrial dysfunction in st...

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Detalhes bibliográficos
Main Authors: Smith, Matthew A., Covington, Marisa D., Schnellmann, Rick G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874586/
https://ncbi.nlm.nih.gov/pubmed/22568896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.04.020
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