Disruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal Injury

Many factors contribute to nervous system dysfunction and failure to regenerate after injury or disease. Here, we describe a previously unrecognized mechanism for nervous system injury. We show that neuronal injury causes rapid, irreversible, and preferential proteolysis of the axon initial segment...

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Autores principales: Schafer, Dorothy P., Jha, Smita, Liu, Fudong, Akella, Trupti, McCullough, Louise D., Rasband, Matthew N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801423/
https://ncbi.nlm.nih.gov/pubmed/19846712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3376-09.2009
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