Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury

The axon initial segment (AIS) cytoskeleton undergoes rapid and irreversible disruption prior to cell death after injury, and loss of AIS integrity can produce profound neurological effects on the nervous system. Here we described a previously unrecognized mechanism for ischemia-induced alterations...

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Udgivet i:iScience
Main Authors: Zhao, Yanan, Wu, Xuanyuan, Chen, Xin, Li, Jianan, Tian, Cuiping, Chen, Jiangrui, Xiao, Cheng, Zhong, Guisheng, He, Shuijin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031317/
https://ncbi.nlm.nih.gov/pubmed/32062456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100880
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