The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria

Diet-induced obesity is associated with proteinuria and glomerular disease in humans and rodents. We have shown that in mice fed a high-fat diet, increased renal expression of the transcriptional factor sterol-regulatory element binding protein-1 (SREBP-1) plays a critical role in renal lipid accumu...

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Bibliografiske detaljer
Main Authors: Wang, Xiaoxin X., Jiang, Tao, Shen, Yan, Adorini, Luciano, Pruzanski, Mark, Gonzalez, Frank J., Scherzer, Pnina, Lewis, Linda, Miyazaki-Anzai, Shinobu, Levi, Moshe
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801344/
https://ncbi.nlm.nih.gov/pubmed/19776172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00404.2009
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