Protein Kinase Cβ Modulates Ligand-induced Cell Surface Death Receptor Accumulation: A MECHANISTIC BASIS FOR ENZASTAURIN-DEATH LIGAND SYNERGY

Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of apoptosis by death ligands such as Fas ligand and tumor necrosis factor-α-related apoptosis-inducing ligand, the mechanism of this protection is...

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Main Authors: Meng, Xue Wei, Heldebrant, Michael P., Flatten, Karen S., Loegering, David A., Dai, Haiming, Schneider, Paula A., Gomez, Timothy S., Peterson, Kevin L., Trushin, Sergey A., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Billadeau, Daniel D., Kaufmann, Scott H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801290/
https://ncbi.nlm.nih.gov/pubmed/19887445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057638
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