Chromosome 21-derived MicroRNAs Provide an Etiological Basis for Aberrant Protein Expression in Human Down Syndrome Brains

Down syndrome (DS), or Trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the human population. Bioinformatic annotation has established that human chromosome 21 (Hsa21) harbors five microRNA (miRNAs) genes: miR-99a, let-7c, miR-125b-2, miR-155, and...

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Detalhes bibliográficos
Main Authors: Kuhn, Donald E., Nuovo, Gerard J., Terry, Alvin V., Martin, Mickey M., Malana, Geraldine E., Sansom, Sarah E., Pleister, Adam P., Beck, Wayne D., Head, Elizabeth, Feldman, David S., Elton, Terry S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
RNA-Mediated Regulation and Noncoding RNAs
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801278/
https://ncbi.nlm.nih.gov/pubmed/19897480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033407
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