Entrapment and Structure of an Extrahelical Guanine Attempting to Enter the Active Site of a Bacterial DNA Glycosylase, MutM

MutM, a bacterial DNA glycosylase, protects genome integrity by catalyzing glycosidic bond cleavage of 8-oxoguanine (oxoG) lesions, thereby initiating base excision DNA repair. The process of searching for and locating oxoG lesions is especially challenging, because of the close structural resemblan...

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Autors principals: Qi, Yan, Spong, Marie C., Nam, Kwangho, Karplus, Martin, Verdine, Gregory L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801272/
https://ncbi.nlm.nih.gov/pubmed/19889642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069799
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