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Differential Interaction of the E3 Ligase Parkin with the Proteasomal Subunit S5a and the Endocytic Protein Eps15

Parkin is a multidomain E3 ligase associated with autosomal recessive Parkinson disease. The N-terminal ubiquitin-like domain (Ubld) of parkin functions with the S5a proteasomal subunit, positioning substrate proteins for degradation. In addition the parkin Ubld recruits the endocytotic protein Eps1...

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Bibliografiske detaljer
Main Authors: Safadi, Susan S., Shaw, Gary S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801268/
https://ncbi.nlm.nih.gov/pubmed/19875440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041970
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