A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

Cullin-3 (CUL3)-based ubiquitin ligases regulate endosome maturation and trafficking of endocytic cargo to lysosomes in mammalian cells. Here, we report that these functions depend on SPOPL, a substrate-specific CUL3 adaptor. We find that SPOPL associates with endosomes and is required for both the...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gschweitl, Michaela, Ulbricht, Anna, Barnes, Christopher A, Enchev, Radoslav I, Stoffel-Studer, Ingrid, Meyer-Schaller, Nathalie, Huotari, Jatta, Yamauchi, Yohei, Greber, Urs F, Helenius, Ari, Peter, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846373/
https://ncbi.nlm.nih.gov/pubmed/27008177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13841
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