Cullin-3 regulates late endosome maturation

Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)–Cul3–Rbx1 ubiquitin E3 ligase complex. Here, we report a previously undescribed role for Cul3 complexes in late endosome (LE) maturation. RNAi-mediated depletion of Cul3 results in a trafficking def...

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Bibliographic Details
Main Authors: Huotari, Jatta, Meyer-Schaller, Nathalie, Hubner, Michaela, Stauffer, Sarah, Katheder, Nadja, Horvath, Peter, Mancini, Roberta, Helenius, Ari, Peter, Matthias
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271891/
https://ncbi.nlm.nih.gov/pubmed/22219362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118744109
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