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The Adenomatous Polyposis Coli-associated Guanine Nucleotide Exchange Factor Asef Is Involved in Angiogenesis

Mutation of the tumor suppressor adenomatous polyposis coli (APC) is a key early event in the development of most colorectal tumors. APC promotes degradation of β-catenin and thereby negatively regulates Wnt signaling, whereas mutated APCs present in colorectal tumor cells are defective in this acti...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Kawasaki, Yoshihiro, Jigami, Takafumi, Furukawa, Shiori, Sagara, Masaki, Echizen, Kanae, Shibata, Yoko, Sato, Rina, Akiyama, Tetsu
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801248/
https://ncbi.nlm.nih.gov/pubmed/19897489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.040691
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