The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice

Sporadic and familial colorectal tumours usually harbour biallelic adenomatous polyposis coli (APC)-associated mutations that result in constitutive activation of Wnt signalling. Furthermore, APC activates Asef and Asef2, which are guanine-nucleotide exchange factors specific for Rac1 and Cdc42. Her...

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Detalhes bibliográficos
Main Authors: Kawasaki, Yoshihiro, Tsuji, Shinnosuke, Muroya, Ken, Furukawa, Shiori, Shibata, Yoko, Okuno, Masumi, Ohwada, Susumu, Akiyama, Tetsu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799213/
https://ncbi.nlm.nih.gov/pubmed/19893577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.233
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