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Conditional Disruption of Pkd1 in Osteoblasts Results in Osteopenia Due to Direct Impairment of Bone Formation

PKD1 (polycystin-1), the disease-causing gene for ADPKD, is widely expressed in various cell types, including osteoblasts, where its function is unknown. Although global inactivation of Pkd1 in mice results in abnormal skeletal development, the presence of polycystic kidneys and perinatal lethality...

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Detaylı Bibliyografya
Asıl Yazarlar: Xiao, Zhousheng, Zhang, Shiqin, Cao, Li, Qiu, Ni, David, Valentin, Quarles, L. Darryl
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801246/
https://ncbi.nlm.nih.gov/pubmed/19887454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050906
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