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Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

We investigated whether Kif3a in osteoblasts has a direct role in regulating postnatal bone formation. We conditionally deleted Kif3a in osteoblasts by crossing osteocalcin (Oc; also known as Bglap)–Cre with Kif3a(flox/null) mice. Conditional Kif3a-null mice (Kif3a(Oc-cKO)) had a 75% reduction in Ki...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Qiu, Ni, Xiao, Zhousheng, Cao, Li, Buechel, Meagan M., David, Valentin, Roan, Esra, Quarles, L. Darryl
פורמט: Artigo
שפה:Inglês
יצא לאור: Company of Biologists 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360919/
https://ncbi.nlm.nih.gov/pubmed/22357948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.095893
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