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Osteoblast-Specific Deletion of Pkd2 Leads to Low-Turnover Osteopenia and Reduced Bone Marrow Adiposity

Polycystin-1 (Pkd1) interacts with polycystin-2 (Pkd2) to form an interdependent signaling complex. Selective deletion of Pkd1 in the osteoblast lineage reciprocally regulates osteoblastogenesis and adipogenesis. The role of Pkd2 in skeletal development has not been defined. To this end, we conditio...

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Vydáno v:PLoS One
Hlavní autoři: Xiao, Zhousheng, Cao, Li, Liang, Yingjuan, Huang, Jinsong, Stern, Amber Rath, Dallas, Mark, Johnson, Mark, Quarles, Leigh Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252138/
https://ncbi.nlm.nih.gov/pubmed/25464512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114198
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