Decreased Superoxide Production in Macrophages of Long-lived p66Shc Knock-out Mice

A decrease in reactive oxygen species (ROS) production has been associated with extended life span in animal models of longevity. Mice deficient in the p66Shc gene are long-lived, and their cells are both resistant to oxidative stress and produce less ROS. Our microarray analysis of p66Shc(−/−) mous...

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Bibliografiska uppgifter
Huvudupphovsmän: Tomilov, Alexey A., Bicocca, Vincent, Schoenfeld, Robert A., Giorgio, Marco, Migliaccio, Enrica, Ramsey, Jon J., Hagopian, Kevork, Pelicci, Pier Giuseppe, Cortopassi, Gino A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801244/
https://ncbi.nlm.nih.gov/pubmed/19892704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017491
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