NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

Hypoxia–ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic excitotoxicity in white matter oligodendrocytes (OLs) mediated by cell surface glutamate receptors (GluRs) of th...

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Hlavní autoři: Manning, Simon M., Talos, Delia M., Zhou, Chengwen, Selip, Debra B., Park, Hyun-Kyung, Park, Chang-Joo, Volpe, Joseph J., Jensen, Frances E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800040/
https://ncbi.nlm.nih.gov/pubmed/18579741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1702-08.2008
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