NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

Hypoxia–ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic excitotoxicity in white matter oligodendrocytes (OLs) mediated by cell surface glutamate receptors (GluRs) of th...

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Autors principals: Manning, Simon M., Talos, Delia M., Zhou, Chengwen, Selip, Debra B., Park, Hyun-Kyung, Park, Chang-Joo, Volpe, Joseph J., Jensen, Frances E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800040/
https://ncbi.nlm.nih.gov/pubmed/18579741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1702-08.2008
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