NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

Hypoxia–ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic excitotoxicity in white matter oligodendrocytes (OLs) mediated by cell surface glutamate receptors (GluRs) of th...

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Detalhes bibliográficos
Main Authors: Manning, Simon M., Talos, Delia M., Zhou, Chengwen, Selip, Debra B., Park, Hyun-Kyung, Park, Chang-Joo, Volpe, Joseph J., Jensen, Frances E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800040/
https://ncbi.nlm.nih.gov/pubmed/18579741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1702-08.2008
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