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Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

Polycystic kidney disease (PKD) is a common human genetic disease with severe medical consequences. Although it is appreciated that the cilium plays a central role in PKD, the underlying mechanism for PKD remains poorly understood and no effective treatment is available. In zebrafish, kidney cyst fo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cao, Ying, Semanchik, Nicole, Lee, Seung Hun, Somlo, Stefan, Barbano, Paolo Emilio, Coifman, Ronald, Sun, Zhaoxia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799791/
https://ncbi.nlm.nih.gov/pubmed/19966229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911987106
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