Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications of this disease. The development of targeted therapies has been limited by t...

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Detalhes bibliográficos
Main Authors: Bradner, James E., Mak, Raymond, Tanguturi, Shyam K., Mazitschek, Ralph, Haggarty, Stephen J., Ross, Kenneth, Chang, Cindy Y., Bosco, Jocelyn, West, Nathan, Morse, Elizabeth, Lin, Katherine, Shen, John Paul, Kwiatkowski, Nicholas P., Gheldof, Nele, Dekker, Job, DeAngelo, Daniel J., Carr, Steven A., Schreiber, Stuart L., Golub, Todd R., Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906581/
https://ncbi.nlm.nih.gov/pubmed/20616024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006774107
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