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A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation

By performing two high-content small molecule screens on DSS- and TNBS-induced zebrafish enterocolitis models of inflammatory bowel disease, we have identified novel anti-inflammatory drugs from the John Hopkins Clinical Compound Library that suppress neutrophilic inflammation. Live imaging of neutr...

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Bibliografische gegevens
Gepubliceerd in:FEBS J
Hoofdauteurs: Oehlers, Stefan H, Flores, Maria Vega, Hall, Christopher J, Wang, Liuyang, Ko, Dennis C, Crosier, Kathryn E, Crosier, Philip S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296212/
https://ncbi.nlm.nih.gov/pubmed/27885812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13976
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