Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

Mutations in the methyl-CpG-binding protein 2 (MeCP2) are associated with Rett syndrome and other neurological disorders. MeCP2 represses transcription mainly by recruiting various co-repressor complexes. Recently, MeCP2 phosphorylation at Ser 80, Ser 229 and Ser 421 was shown to occur in the brain...

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Dettagli Bibliografici
Autori principali: Bracaglia, Giorgia, Conca, Barbara, Bergo, Anna, Rusconi, Laura, Zhou, Zhaolan, Greenberg, Michael E, Landsberger, Nicoletta, Soddu, Silvia, Kilstrup-Nielsen, Charlotte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
Soggetti:
Scientific Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799202/
https://ncbi.nlm.nih.gov/pubmed/19820693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.217
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