Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis

Mutations within codon 306 of the Mycobacterium tuberculosis embB gene modestly increase ethambutol (EMB) MICs. To identify other causes of EMB resistance and to identify causes of high-level resistance, we generated EMB-resistant M. tuberculosis isolates in vitro and performed allelic exchange stud...

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Hauptverfasser: Safi, Hassan, Fleischmann, Robert D., Peterson, Scott N., Jones, Marcus B., Jarrahi, Behnam, Alland, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798522/
https://ncbi.nlm.nih.gov/pubmed/19822701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01288-09
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