Enhanced PD-1 Expression by T Cells in Cerebrospinal Fluid Does Not Reflect Functional Exhaustion during Chronic Human Immunodeficiency Virus Type 1 Infection

During chronic viral infections, T cells are exhausted due to constant antigen exposure and are associated with enhanced programmed death 1 (PD-1) expression. Deficiencies in the PD-1/programmed death-ligand 1 (PD-L1) pathway are associated with autoimmune diseases, including those of the central ne...

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Hlavní autoři: Sadagopal, Shanmugalakshmi, Lorey, Shelly L., Barnett, Louise, Sutherland, Deborah, Basham, Rebecca, Erdem, Husamettin, Kalams, Spyros A., Haas, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798447/
https://ncbi.nlm.nih.gov/pubmed/19828602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01181-09
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