Expansion and Exhaustion of T-Cell Responses during Mutational Escape from Long-Term Viral Control in Two DNA/Modified Vaccinia Virus Ankara-Vaccinated and Simian-Human Immunodeficiency Virus SHIV-89.6P-Challenged Macaques

In this study, we monitored the temporal breadths, frequencies, and functions of antiviral CD4 and CD8 T cells in 2 of 22 DNA/modified vaccinia virus Ankara-vaccinated macaques that lost control of a simian-human immunodeficiency virus 89.6P challenge by 196 weeks postchallenge. Our results show tha...

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Detalhes bibliográficos
Main Authors: Sadagopal, Shanmugalakshmi, Amara, Rama Rao, Kannanganat, Sunil, Sharma, Sunita, Chennareddi, Lakshmi, Robinson, Harriet L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292989/
https://ncbi.nlm.nih.gov/pubmed/18234787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02242-07
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