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Evaluation of CD4-CD4i Antibody Architectures Yields Potent, Broadly Cross-Reactive Anti-Human Immunodeficiency Virus Reagents

The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) has several adaptations that allow the virus to evade antibody neutralization. Nevertheless, a few broadly cross-reactive neutralizing antibodies as well as reagents containing portions of CD4, the HIV receptor, have demonstrat...

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Detalhes bibliográficos
Main Authors: West, Anthony P., Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Klein, Joshua S., Bjorkman, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798438/
https://ncbi.nlm.nih.gov/pubmed/19864392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01528-09
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