Design and Expression of a Dimeric Form of Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency

The antigen-binding fragment of the broadly neutralizing human immunodeficiency virus type 1 (HIV-1) antibody 2G12 has an unusual three-dimensional (3D) domain-swapped structure with two aligned combining sites that facilitates recognition of its carbohydrate epitope on gp120. When expressed as an i...

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Main Authors: West, Anthony P., Galimidi, Rachel P., Foglesong, Christopher P., Gnanapragasam, Priyanthi N. P., Huey-Tubman, Kathryn E., Klein, Joshua S., Suzuki, Maria D., Tiangco, Noreen E., Vielmetter, Jost, Bjorkman, Pamela J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612297/
https://ncbi.nlm.nih.gov/pubmed/18945777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01564-08
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