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In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of Mitogen Activated Protein Kinase/Extracellular Signal-regulated Kinase 1/2 kinase
PURPOSE: The Mitogen-activated Protein Kinase (MAPK) pathway is important for cell proliferation, survival and differentiation and is frequently upregulated in cancers. The MAPK pathway is also activated after exposure to ionizing radiation. We investigated the effects of AZD6244 (ARRY-142886), an i...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798161/ https://ncbi.nlm.nih.gov/pubmed/19366835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2954 |
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