Nuclear β-Catenin Induces an Early Liver Progenitor Phenotype in Hepatocellular Carcinoma and Promotes Tumor Recurrence

Transforming growth factor-β cooperates with oncogenic Ras to activate nuclear β-catenin during the epithelial to mesenchymal transition of hepatocytes, a process relevant in the progression of hepatocellular carcinoma (HCC). In this study we investigated the role of β-catenin in the differentiation...

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Bibliographische Detailangaben
Hauptverfasser: Zulehner, Gudrun, Mikula, Mario, Schneller, Doris, van Zijl, Franziska, Huber, Heidemarie, Sieghart, Wolfgang, Grasl-Kraupp, Bettina, Waldhör, Thomas, Peck-Radosavljevic, Markus, Beug, Hartmut, Mikulits, Wolfgang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2010
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797905/
https://ncbi.nlm.nih.gov/pubmed/20008139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090300
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