Inhibition of SOC/Ca(2+)/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells

BACKGROUND: Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC) is unclear. Nuclear translocation of nuclear factor o...

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Detalhes bibliográficos
Main Authors: Wang, Cong, Li, Ji-Feng, Zhao, Lan, Liu, Jie, Wan, Jun, Wang, Yue Xiu, Wang, Jun, Wang, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797778/
https://ncbi.nlm.nih.gov/pubmed/20003325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-123
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