Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells

The up-regulation of transient receptor potential channel 6 (TRPC6) has been found to contribute to the proliferation of pulmonary artery smooth muscle cells (PASMCs), and inhibition of phosphodiesterase-5 (PDE5) has been shown to suppress TRPC6 expression in PASMCs. However, the molecular mechanism...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Shaojun, Pan, Yilin, Ke, Rui, Xie, Xinming, Zhai, Cui, Shi, Wenhua, Wang, Jian, Yan, Xin, Chai, Limin, Wang, Qingting, Zhang, Qianqian, Su, Xiaofan, Yang, Lan, Gao, Li, Li, Manxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519690/
https://ncbi.nlm.nih.gov/pubmed/28729555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06350-5
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