Inhibition of SOC/Ca<sup>2+</sup>/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells

<p>Abstract</p> <p>Background</p> <p>Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC...

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Hlavní autoři: Liu Jie, Zhao Lan, Li Ji-Feng, Wang Cong, Wan Jun, Wang Yue, Wang Jun, Wang Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2009-12-01
Edice:Respiratory Research
On-line přístup:http://respiratory-research.com/content/10/1/123
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