Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor

[Image: see text] The Cu(I) sensor Mycobacterium tuberculosis CsoR is a founding member of a new metalloregulatory protein family. Here we show that two "atom" substitutions of the Nε2 face of a Cu(I) coordinating histisine-61 allosterically uncouple Cu(I) and DNA binding, with no effect o...

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Detalhes bibliográficos
Main Authors: Ma, Zhen, Cowart, Darin M., Ward, Brian P., Arnold, Randy J., DiMarchi, Richard D., Zhang, Limei, George, Graham N., Scott, Robert A., Giedroc, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797707/
https://ncbi.nlm.nih.gov/pubmed/19928961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja908372b
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