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Efficient repair of DNA double-strand breaks in malignant cells with structural instability

Aberrant repair of DNA double strand breaks (DSBs) is thought to be important in the generation of gross chromosomal rearrangements (GCRs). To examine how DNA DSBs might lead to GCRs, we investigated the repair of a single DNA DSB in a structurally unstable cell line. An I-SceI recognition site was...

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Detalhes bibliográficos
Main Authors: Cheng, Yue, Zhang, Zhenhua, Keenan, Bridget, Roschke, Anna V., Nakahara, Kenneth, Aplan, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797445/
https://ncbi.nlm.nih.gov/pubmed/19909760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.10.016
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