A Slow ATP-induced Conformational Change Limits the Rate of DNA Binding but Not the Rate of β Clamp Binding by the Escherichia coli γ Complex Clamp Loader

In Escherichia coli, the γ complex clamp loader loads the β-sliding clamp onto DNA. The β clamp tethers DNA polymerase III to DNA and enhances the efficiency of replication by increasing the processivity of DNA synthesis. In the presence of ATP, γ complex binds β and DNA to form a ternary complex. B...

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Bibliographic Details
Main Authors: Thompson, Jennifer A., Paschall, Christopher O., O'Donnell, Mike, Bloom, Linda B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797285/
https://ncbi.nlm.nih.gov/pubmed/19759003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045997
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