Targeting Human Epidermal Growth Factor Receptor Signaling with the Neuregulin's Heparin-binding Domain

A major limitation in biopharmaceutical development is selectively targeting drugs to diseased tissues. Growth factors and viruses have solved this problem by targeting tissue-specific cell-surface heparan sulfates. Neuregulin (NRG), a growth factor important in both nervous system development and c...

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Detalhes bibliográficos
Main Authors: Ma, Zhenzhong, li, Qunfang, An, Haiqian, Pankonin, Mark S., Wang, Jiajing, Loeb, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797281/
https://ncbi.nlm.nih.gov/pubmed/19717564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032714
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