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Molecular Basis of Transcriptional Mutagenesis at 8-Oxoguanine
Structure-function analysis has revealed the mechanism of yeast RNA polymerase II transcription at 8-oxoguanine (8-oxoG), the major DNA lesion resulting from oxidative stress. When polymerase II encounters 8-oxoG in the DNA template strand, it can misincorporate adenine, which forms a Hoogsteen bp w...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797236/ https://ncbi.nlm.nih.gov/pubmed/19758983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022764 |
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