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8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells
8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, t...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596238/ https://ncbi.nlm.nih.gov/pubmed/19020090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806464105 |
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