Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences

To assess the role of the Ogg1 DNA glycosylase in the transcription-coupled repair (TCR) of the mutagenic lesion, 7,8-dihydro-8oxoguanine (8-OxoG), we have investigated the removal of this lesion in wild-type and ogg1(−/−) null mouse embryo fibroblast (MEF) cell lines. We used nonreplicating plasmid...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Le Page, Florence, Klungland, Arne, Barnes, Deborah E., Sarasin, Alain, Boiteux, Serge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26959/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140137297
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