Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences

To assess the role of the Ogg1 DNA glycosylase in the transcription-coupled repair (TCR) of the mutagenic lesion, 7,8-dihydro-8oxoguanine (8-OxoG), we have investigated the removal of this lesion in wild-type and ogg1(−/−) null mouse embryo fibroblast (MEF) cell lines. We used nonreplicating plasmid...

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Hlavní autoři: Le Page, Florence, Klungland, Arne, Barnes, Deborah E., Sarasin, Alain, Boiteux, Serge
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC26959/
https://ncbi.nlm.nih.gov/pubmed/10890888
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