Protective Role of Cys-178 against the Inactivation and Oligomerization of Human Insulin-degrading Enzyme by Oxidation and Nitrosylation

Insulin-degrading enzyme (IDE), a 110-kDa metalloendopeptidase, hydrolyzes several physiologically relevant peptides, including insulin and amyloid-β (Aβ). Human IDE has 13 cysteines and is inhibited by hydrogen peroxide and S-nitrosoglutathione (GSNO), donors of reactive oxygen and nitrogen species...

Full description

Saved in:
Bibliographic Details
Main Authors: Ralat, Luis A., Ren, Min, Schilling, Alexander B., Tang, Wei-Jen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797171/
https://ncbi.nlm.nih.gov/pubmed/19808678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030627
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items