Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

Cullin-based E3 ubiquitin ligases are activated through covalent modification of the cullin subunit by the ubiquitin-like protein Nedd8. Cullin neddylation dissociates the ligase assembly inhibitor Cand1, and promotes E2 recruitment and ubiquitin transfer by inducing a conformational change. Here, w...

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Bibliographic Details
Main Authors: Siergiejuk, Edyta, Scott, Daniel C, Schulman, Brenda A, Hofmann, Kay, Kurz, Thimo, Peter, Matthias
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797064/
https://ncbi.nlm.nih.gov/pubmed/19942853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.354
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