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Regulation of the Metastasis Suppressor Gene MKK4 in Ovarian Cancer

OBJECTIVES: MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcinogenesis. METHODS: Bisulfite sequencing was...

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Detalhes bibliográficos
Main Authors: Spillman, Monique A., Lacy, Judith, Murphy, Susan K., Whitaker, Regina S., Grace, Lisa, Teaberry, Vanessa, Marks, Jeffrey R., Berchuck, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796629/
https://ncbi.nlm.nih.gov/pubmed/17276500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2006.12.017
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