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Regulation of the Metastasis Suppressor Gene MKK4 in Ovarian Cancer

OBJECTIVES: MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcinogenesis. METHODS: Bisulfite sequencing was...

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書誌詳細
主要な著者: Spillman, Monique A., Lacy, Judith, Murphy, Susan K., Whitaker, Regina S., Grace, Lisa, Teaberry, Vanessa, Marks, Jeffrey R., Berchuck, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796629/
https://ncbi.nlm.nih.gov/pubmed/17276500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2006.12.017
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