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Enantioselective Rhodium-Catalyzed [2+2+2] Cycloadditions of Terminal Alkynes and Alkenyl Isocyanates: Mechanistic Insights Lead to a Unified Model that Rationalizes Product Selectivity

[Image: see text] This manuscript describes the development and scope of the asymmetric rhodium-catalyzed [2+2+2] cycloaddition of terminal alkynes and alkenyl isocyanates leading to the formation of indolizidine and quinolizidine scaffolds. The use of phosphoramidite ligands proved crucial for avoi...

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Détails bibliographiques
Auteurs principaux: Dalton, Derek M., Oberg, Kevin M., Yu, Robert T., Lee, Ernest E., Perreault, Stéphane, Oinen, Mark Emil, Pease, Melissa L., Malik, Guillaume, Rovis, Tomislav
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796191/
https://ncbi.nlm.nih.gov/pubmed/19817441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja905065j
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