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Enantioselective Synthesis of Indolizidines Bearing Quaternary Substituted Stereocenters via Rhodium-Catalyzed [2+2+2] Cycloaddition of Alkenyl Isocyanates and Terminal Alkynes

[Image: see text] An enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters by way of a rhodium catalyzed [2+2+2] cycloaddition of substituted alkenyl isocyanates and terminal alkynes is described. The reaction provides lactam products using aliphatic alkynes, while...

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Dettagli Bibliografici
Autori principali: Lee, Ernest E., Rovis, Tomislav
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747361/
https://ncbi.nlm.nih.gov/pubmed/18284249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol800086s
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