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Predictable and Regioselective Insertion of Internal Unsymmetrical Alkynes in Rhodium-Catalyzed Cycloadditions with Alkenyl Isocyanates

A regioselective, rhodium-catalyzed cycloaddition between a variety of internal, unsymmetrical alkynes is described. We document the impact of both steric and electronic properties of the alkyne on reaction course, efficiency and enantioselectivity. The substituent that better stabilizes a positive...

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Detalhes bibliográficos
Main Authors: Friedman, Rebecca Keller, Rovis, Tomislav
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737069/
https://ncbi.nlm.nih.gov/pubmed/19569692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903899c
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