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Predictable and Regioselective Insertion of Internal Unsymmetrical Alkynes in Rhodium-Catalyzed Cycloadditions with Alkenyl Isocyanates

A regioselective, rhodium-catalyzed cycloaddition between a variety of internal, unsymmetrical alkynes is described. We document the impact of both steric and electronic properties of the alkyne on reaction course, efficiency and enantioselectivity. The substituent that better stabilizes a positive...

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Bibliographic Details
Main Authors: Friedman, Rebecca Keller, Rovis, Tomislav
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737069/
https://ncbi.nlm.nih.gov/pubmed/19569692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903899c
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