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Essential roles of CKIδ and CKIε in the mammalian circadian clock
Circadian rhythms in mammals are generated by a negative transcriptional feedback loop in which PERIOD (PER) is rate-limiting for feedback inhibition. Casein kinases Iδ and Iε (CKIδ/ε) can regulate temporal abundance/activity of PER by phosphorylation-mediated degradation and cellular localization....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795500/ https://ncbi.nlm.nih.gov/pubmed/19948962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906651106 |
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